Phosphorylation of NF-kappa B p65 by PKA stimulates ... - PubMed
The transcriptional activity of NF-kappa B is stimulated upon phosphorylation of its p65 subunit on serine 276 by protein kinase A (PKA). The transcriptional coactivator CPB/p300 associates …
Pathway干货 | NF-Kb 信号通路简介 - 知乎 - 知乎专栏
包括p65的磷酸化调节和p65的乙酰化调节、p53对转录的竞争性调节，gsk3β对转录的间接调节；nf-κb转录调节中的常见的激酶：pka（蛋白激酶a），msk1和msk2（分裂素和压力激活激酶 …
The Regulation of NF-κB Subunits by Phosphorylation - PMC
In resting cells the PKA catalytic subunit (PKA-C) is bound in an inactive state to cytosolic IκBα: p65 complexes. Following IKK complex activation and the degradation of IκBα, active PKA-C …
Phosphorylation of NF-κB p65 by PKA Stimulates ... - ScienceDirect
1998年4月1日 · Phosphorylation by PKA both weakens the interaction between the N- and C-terminal regions of p65 and creates an additional site for interaction with CBP/p300. Therefore, …
A most versatile kinase: The catalytic subunit of PKA
2021年1月1日 · Furthermore, PKA can phosphorylate the NF-κB subunit p65, a transcription factor that is essential for T-cell activation, independently of cAMP. This phosphorylation of …
The Transcriptional Activity of NF-κB Is Regulated by the IκB ...
1997年5月2日 · Dephosphorylation of nuclear extracts from induced cells reduces the DNA-binding activity of NF-κB in vitro. In addition, PKA can phosphorylate the recombinant p65–p65 …
Phosphorylation of NF-κB p65 by PKA Stimulates ... - Cell Press
Phosphorylation by PKA both weakens the interaction between the N- and C-terminal regions of p65 and creates an additional site for interaction with CBP/p300. Therefore, PKA regulates the …
PDE4B Modulates Phosphorylation of p65 (Ser468) via cAMP/PKA …
2025年2月16日 · In MH-S cells, luciferase analysis indicated that PDE4B acts as a positive regulator of p65 in inflammation. PKA inhibitor (H-89) increased pP65 and PDE4B expression, …
Protein Kinase A-Induced Phosphorylation of the p65 Subunit of …
In this report, we demonstrate that PKA activation in Schwann cells leads to phosphorylation of p65 at serine 276, and this increases its transcriptional activity. This phosphorylation of NF-κB …
Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein ... - PubMed
2009年10月1日 · Here, we investigated the prevalence and function of p65-Ser276 phosphorylation by protein kinase A (PKA) in the malignant phenotype and gene …