Apr 20, 2022 · Chemotaxis of fibroblasts and other mesenchymal cells is critical for embryonic development and wound healing. Fibroblast chemotaxis directed by a gradient of platelet …

磷酸肌醇特异性磷脂酶 c (plc) 在跨膜信号转导中扮演重要角色。响应细胞外刺激，如激素、生长因子和神经递质刺激后，plc 水解磷脂酰肌醇-4,5 二磷酸 (pip2) 并产生第二信使肌糖 1,4,5 三磷 …

Apr 2, 2025 · PLC activity is largely regulated by phosphorylation. For example, phosphorylation of PLCβ3 at Ser1105 by PKA or PKC inhibits activity, whereas phosphorylation of PLCγ at Tyr …

Jul 9, 2001 · PLC and PKC are two crucial components of the PI signaling system. Both PKC and PLC have been shown to be involved in a variety of physiological functions, such as synthesis, …

PLC is a cytoplasmic protein that controls the levels of PIP 2 in cells by localizing within or outside of lipid rafts in the plasma membrane and catalyzing the hydrolysis of phosphorylated forms of …

Feb 15, 2000 · The protein kinase C (PKC) family of signal transducers are characterized by a dependence upon lipids for activity. Specifically, the classical (cPKCα, β and γ) and novel …

Extracellular stimuli trigger activation of the PLC/PKC/PKD signaling axis, which controls several signaling pathways. Here, we concentrate on the novel functions of PLC/PKC/PKD signaling in …

These PKA-independent actions of GLP-1 depend on protein kinase C (PKC), involve activation of the standard GLP-1 receptor (GLP1R) and culminate in activation of phospholipase C (PLC), …

Mar 1, 2024 · Members of the PKC family are recognized as the main intracellular receptors for the lipid second messenger 1,2-diacylglycerol (DAG), which together with inositol-1,4,5 …

We shall discuss two main isoforms of PLC: PLC-β, which is activated by a subset of trimeric G proteins (Gα q and Gα 0), and PLC-γ, which, in contrast, associates with phosphotyrosines on …