2023年9月1日 · In this study, we used ATAC-seq to investigate changes in chromatin accessibility upon specific depletion of two ribosome biogenesis components, RPOA-2 and GRWD-1, in the …

Genes encoding ribosomal RNA (rDNA) are organized into a repetitive array in eukaryotic genomes. The copy number of these genes often varies and is responsive to genetics and …

2018年10月18日 · Combining MAD with an improved ATAC-seq method, we find that increasing proteasome activity reduces rDNA instability usually observed in aging cells and, contrary to …

2024年12月12日 · Age-linked DNA hypermethylation throughout the rDNA constitutes a robust “methylation clock” that accurately reports age, yet the consequences of hypermethylation on …

2023年8月20日 · The Assay for Transposase-Accessible Chromatin (ATAC-seq) 2 and Whole-Genome Bisulfite Sequencing (WGBS) 3 have emerged as effective NGS methods for profiling …

Of note, rDNA indeed appears to be extremely accessible in short-read assays; around half of reads in a typical yeast ATAC-seq dataset originate from rDNA arrays (Supplementary Fig. …

2020年5月15日 · ATAC-seq in gliomas and glioblastomas identify hundreds of eccDNAs, including one containing the well-known EGFR gene amplicon from chr7. More than 18,000 …

2023年4月21日 · 华南农业大学园艺学院李雪萍教授和朱孝扬教授团队针对1-MCP不同处理时间点利用ATAC-seq评估成熟过程中染色质可及性差异，RNA-seq探究差异表达基因，通过联合分 …

ATAC-seq (Assay for Transposase-Accessible Chromatin with high-throughput sequencing) provides an efficient way to analyze nucleosome-free regions and has been applied widely to …

In this study, we used ATAC-seq to investigate changes in chromatin accessibility upon specific depletion of two ribosome biogenesis components, RPOA-2 and GRWD-1, in the model …