Genes encoding ribosomal RNA (rDNA) are essential for cell survival and are particularly sensitive to factors leading to genomic instability. Their repetitive character makes them prone to inappropriate recombinational events arising from collision of transcriptional and replication machineries, resulting in unstable rDNA copy numbers.

The updated version of the animal rDNA loci database (http://www.animalrdnadatabase.com/) presents a source of information about rDNA loci in a wide range of animal genera. Its new options allow the retrieval of information about the expression activity of rDNA loci and their position on different chromosome types.

Nucleoli form around actively transcribed ribosomal RNA (rRNA) genes (rDNA), and the morphology and location of nucleolus-associated genomic domains (NADs) are linked to the RNA Polymerase I (Pol I) transcription status.

2008年5月16日 · Here, we describe eNoSC, a protein complex that senses energy status and controls rRNA transcription. eNoSC contains Nucleomethylin, which binds histone H3 dimethylated Lys9 in the rDNA locus, in a complex with SIRT1 and SUV39H1.

2012年4月1日 · This study revealed dispersion of rDNA loci into four chromosomes in diploids and existence of some species of Camellia in different ploidy levels. For instance, Camellia reticulata exists in diploid, tetraploid and hexaploid forms. Further, it demonstrated that most of the rDNA signals were

2001年2月1日 · In this review, we summarize current knowledge on the structure and organization of rDNA, its role in sensing changes in the genome, and its linkage to aging. We also review recent findings on the main factors involved in chromatin assembly and DNA repair in the maintenance of rDNA stability in the model plants Arabidopsis thaliana and the moss ...

2020年7月10日 · The ribosomal DNA (rDNA) locus in Saccharomyces cerevisiae is one of the most highly transcribed loci, and accounts for 60% of cellular transcription [1].

2017年2月23日 · Here, we discuss key mechanisms that maintain rDNA repeats, telomeres, and transposons in yeast and human before highlighting emerging roles for non-canonical DNA structures at these repetitive loci. KEYWORDS: genome stability, rDNA (rDNA), repetitive DNA, retrotransposons, telomeres.

The animal rDNA database provides currently information on number and position of rDNA loci for 2800 animal species from 340 families. The data of this second release comes from 1040 papers based on in situ hybridization of 5S and 45S rDNA, published until March 2021. You can also find several new features in advanced search, such as type of ...

2019年5月28日 · rDNA, the genes encoding the RNA components of ribosomes (rRNA), are highly repetitive in all eukaryotic genomes, containing 100s to 1000s of copies, to meet the demand for ribosome biogenesis. rDNA genes are arranged in large stretches of tandem repeats, forming loci that are highly susceptible to copy loss due to their repetitiveness and ...