The associations of NSUN2/IGF-II signature with the risks of death and relapse remained significant in multivariate Cox regression models. Random-effects meta-analyses show the …

2005年4月14日 · PKB and ribosomal S6 kinase (RSK) both phosphorylated METTL1 at Ser27 in vitro. Ser27 became phosphorylated when HEK293 cells were stimulated with insulin‐like growth factor‐1 (IGF‐1) and this was prevented by inhibition of phosphatidyinositol 3‐kinase.

摘要： 胰岛素样生长因子（insulin-like growth factors，IGFs）是一个多功能的生长因子家族，对细胞的生长、分化和凋亡起着重要的调节作用。 概述近年来在IGFs的成分、结构功能、信号通路以及在疾病中的作用等方面的研究进展，以期为细胞生长调控、动物胚胎发育及肿瘤发生等方面的研究提供参考。 Abstract: Insulin-like growth factors（IGFs）is a multifunctional growth factor family, and plays an important role in cell growth, differentiation and apoptosis.

In tRNA, numerous types of tRNA modifications and modifying enzymes have been implicated in biological functions and human diseases. In our review, we talk about the relevant biological functions of tRNA modifications, including tRNA stability, protein translation, cell cycle, oxidative stress, and immunity.

2021年12月3日 · Insulin-like growth factor 1 (IGF-1) is considered to be a crucial gene in the animal development of bone and body size. In this study, a unique synonymous mutation (c.258 A > G) of the IGF-1 gene was modified with an adenine base editor to observe the growth and developmental situation of mutant mice.

IGF-I/IGF-1 Protein, Human (70a.a)是一种促进有丝分裂的细胞因子，与 IGF 受体结合，能够调节多种组织的生长，如神经组织、淋巴组织、生殖组织、平滑肌、内皮细胞和骨骼等，同时具有调节神经保护的作用。 LR3 IGF-I/IGF-1 蛋白与胰岛素相似，具有超过胰岛素功效的强效生长促进活性。 作为一种潜在的生理调节剂，即使浓度显着低于胰岛素，它也能刺激成骨细胞中的葡萄糖转运和糖原合成。 LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) 是重组的 LR3 IGF-I/IGF-1 蛋 …

NSUN2, as a tRNA methyltransferase, modifies both tRNAs and mRNAs by adding m 5 C methylation to RNAs. NSUN2 is essential factor for maintenance of self-renewal and differentiation in stem cells [24, 50, 51].

2017年8月22日 · Results: Patients with NSUN2 (high) IGF-II (low) had significantly superior overall and disease progression-free survival, followed by NSUN2 (low) IGF-II (low), NSUN2 (high) IGF-II (high) and...

Rat IGF-I DNA for insulin-like growth factor I1 (IGF-II) in rat embryos sequence has not been described but the mouse probe gives satisfactory results because the gene is highly conserved Abbreviations used: IGF-I and -11, insulin-like growth factors I and (for example, there are only three mismatches when the 11. respectively. mouse probe is ...

2021年3月4日 · Analysis of RNA-Seq data identified 950 high-confidence tRFs, and the results suggested that tRNA pools are dramatically distinct across the samples in terms of expression profiles and tRF ...