Tcf3 represses Wnt-β-catenin signaling and maintains neural …
2014年5月15日 · We found Tcf3 to be a repressor of Wnt signaling in neocortical NPCs in a reporter gene assay. Tcf3 bound to the promoter of the proneural bHLH gene Neurogenin1 …
Function of Wnt/β-catenin in counteracting Tcf3 repression
In this study, we genetically define Tcf3-β-catenin functions in mice by generating a Tcf3ΔN knock-in mutation that specifically ablates Tcf3-β-catenin. Mouse embryos homozygous for …
Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt ... - Nature
2021年6月28日 · We demonstrate that Rspo2 promotes anterior development by inhibiting TCF3 phosphorylation and Wnt target genes activation, possibly independently of the known …
TCF3 基因参与哪些基因调控网络或通路？ - 知乎
1. Wnt信号通路：TCF3与β-catenin相互作用，参与Wnt信号通路的调控。这个通路在胚胎发育、细胞增殖和干细胞自我更新中起关键作用。 2. B细胞发育：TCF3在B细胞发育中扮演重要角 …
Tcf3 和 Tcf1 的相反作用控制胚胎干细胞自我更新的 Wnt 刺激 …
Tcf3 的基因消融取代了对 ESC 自我更新的外源 Wnt3a 或 GS K3 抑制的要求，证明 Tcf3 阻遏物的抑制是 Wnt 信号传导的必要下游效应。 有趣的是，Tcf3-β-catenin 和 Tcf1-β-catenin 相互作 …
Regulation of TCF3 by Wnt-dependent phosphorylation during …
TCF3 is a transcriptional repressor that has been implicated in Wnt signaling and plays key roles in embryonic axis specification and stem cell differentiation. Here we demonstrate that Wnt …
Function of Wnt/β-catenin in counteracting Tcf3 repression through the ...
Wnt3a-stimulated reduction of Tcf3 occupancy on target genes supports this model by providing a mechanism of inhibiting repression. The Tcf/Lef circuit model suggests that Tcf3 represses an …
Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of
2011年6月19日 · Genetic ablation of Tcf3 replaced the requirement for exogenous Wnt3a or GSK3 inhibition for ESC self-renewal, demonstrating that inhibition of Tcf3 repressor is the …
In vivo transcriptional governance of hair follicle stem cells by ...
2014年1月26日 · Hair follicle stem cells (HFSCs) regenerate hair in response to Wnt signalling. Here, we unfold genome-wide transcriptional and chromatin landscapes of β …
Targeting the interaction of β-catenin and TCF/LEF transcription ...
2022年9月15日 · In the nucleus, T cell factor (TCF) and lymphoid enhancer-binding factor (LEF) proteins interact with transcriptional co-repressors from the Groucho/TLE family, blocking the …