TIE2受体是一种酪氨酸激酶受体，含有表皮生长因子同源基序、免疫球蛋白样环和纤维连接蛋白III型重复序列，在内皮和造血干细胞中表达，并与四种血管生成素结合。 TIE2受体广泛表达于静息内皮细胞表面，也由造血细胞亚群（如肿瘤浸润性髓样细胞）以及周细胞表达，尽管其水平低于内皮细胞。 TIE2的磷酸化通过配体和其他细胞表面蛋白的独特组合进行微调。 表达TIE2的单核细胞/巨噬细胞（TEM）是一个髓样细胞亚群。 TEM存在于人和小鼠的循环和肿瘤中，ANG2通过 …

In cancer, Tie2 was originally found to be overexpressed in tumoral vessels. More recently, our laboratory and others have found that Tie2 is also expressed outside the vascular compartment in several types of cancer, including leukemia and solid neoplasms such as gastric tumors, breast tumors, and gliomas.

Here we review the importance, and ways to inhibit the function, of one therapeutic target: the receptor Tie2. Tie2 is a receptor present on the cell surface of several cell types within the tumor microenvironment and regulates tumor angiogenesis, growth, and metastasis to distant organs.

2020年5月14日 · Targeting this newly identified ERβ/ANGPT-2/Tie-2 signaling pathway with the FDA-approved anti-estrogen, Faslodex, may help in the development of a novel combined therapy with sunitinib to...

2017年5月19日 · Angiopoietin ligands (ANG1–ANG4) and the TIE (TIE1 and TIE2) receptor tyrosine kinases form an endothelial signalling pathway that is necessary for embryonic cardiovascular and lymphatic...

2020年9月27日 · Tie2阳性单核巨噬细胞(Tie2 expressing monocytes/macrophages, TEMs)是表达酪氨酸激酶受体Tie2(tyrosine kinase receptors with immunoglobulin and EGF homology domains receptors-2)的单核巨噬细胞，是促血管生成和组织重塑功能极强的TAMs亚群 。

2016年1月19日 · We found that this Tie-2High population exists mainly in prostate cancer cell lines that are capable of metastasizing to the bone. These cells not only express a higher level of CSC markers but also demonstrate enhanced resistance …

In this study, we show that Tie-2 is expressed by a rare population of prostate cancer cells that co-express several CSC markers. Compared to the Tie-2 Low population, Tie-2 High prostate cancer cells demonstrate not only enhanced chemoresistance but also an increased ability to adhere to stromal cells such as endothelial cells and osteoblasts.

Studies have shown that the overexpression of ANGPT2 and higher ANGPT2/ANGPT1 ratios, compared with normal tissues, correlated with poor prognosis in many cancers, including acute myeloid ...

TIE-2 expressing monocytes (TEM) were found both in humans and mice. Here, we review the phenotypes and functions of TEM reported so far in human cancer and their potential use as markers of cancer progression and metastasis. Finally, we discuss the therapeutic approaches currently used or proposed to target TEM.