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Niacin, also known as vitamin B3, is known for its plethora of health benefits and has long been studied independently in comparison to a lesser known compound called NR (nicotinamide riboside). Although both of these molecules have sirtuin 1 activation capabilities, they differ in how and where they act. While niacin is transported directly into the cell, raising NAD levels by serving as a precursor, NR activates sirtuin 1 through transport by sirt5. This results in an increase of ATP productio