“Ozempic face” We’ve all heard of it, now listen to what Dr. Z has to say about it! While Ozempic is safe to use with a doctor’s recommendation, it can cause rapid weight loss that is often more pronounced on the face. Weight loss can cause dermatological changes and shrinking because the fat that stretches and cushions the skin is no longer in place. The skin of the face also loses its ability to retract after an episode of rapid weight loss due to reduced levels of elastin and collagen, which