Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction

Shape and dimension. (a) Tropomyosin, a 70 -kd muscle protein, is a two-stranded α-helical coiled coil. Estimate the length of the molecule. (b) Suppose that a 40 -residue segment of a protein folds into a two-stranded antiparallel βstructure with a 4 residue hairpin turn. What is the longest dimension of this motif? | Numerade

Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC inhibitors using fragment-based methods and structure-based design

SOLVED: DNA is coiled around nucleosomes, forming the structural unit of a chromosome called chromatin.

Proteins I: Structure and Function