Part 1: Proton pump inhibitors are among the most prescribed medications in the world.Many people will start a proton pump inhibitor and continue it for the rest of their life Despite the fact that proton pump inhibitors were never intended to be used to beyond eight weeks. Physical dependence to proton pump inhibitors may occur within two weeks of use. Discontinuing a PPI once one has become dependent can be extremely difficult due to rebound acid reflux. In fact, a person who took a PPI for an