Gdhj - Search Videos

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Glutamate dehydrogenase Function

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SOLVED: The glutamate side chain in the active site of HMG-CoA reductase acts as a general base only after conformational change triggers the exchange of NADP for NADPH. The mevalonate binds to the active site. CoA is reduced to CoA-SH: it attacks the carbonyl center of the second NADPH hydride from the aldehyde.

SOLVED: The glutamate side chain in the active site of HMG-CoA reductase acts as a general base only after conformational change triggers the exchange of NADP for NADPH. The mevalonate binds to the active site. CoA is reduced to CoA-SH: it attacks the carbonyl center of the second NADPH hydride from the aldehyde.

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